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Programmed activation of cancer cell apoptosis: A tumor-targeted phototherapeutic topoisomerase I inhibitor

We report here a tumor-targeting masked phototherapeutic agent 1 (PT-1). This system contains SN-38—a prodrug of the topoisomerase I inhibitor irinotecan. Topoisomerase I is a vital enzyme that controls DNA topology during replication, transcription, and recombination. An elevated level of topoisome...

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Detalles Bibliográficos
Autores principales:	Shin, Weon Sup, Han, Jiyou, Kumar, Rajesh, Lee, Gyung Gyu, Sessler, Jonathan L., Kim, Jong-Hoon, Kim, Jong Seung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931442/ https://www.ncbi.nlm.nih.gov/pubmed/27374023 http://dx.doi.org/10.1038/srep29018

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