Positive Cofactor 4 (PC4) is critical for DNA repair pathway re-routing in DT40 cells

PC4 is an abundant single-strand DNA binding protein that has been implicated in transcription and DNA repair. Here, we show that PC4 is involved in the cellular DNA damage response. To elucidate the role, we used the DT40 chicken B cell model, which produces clustered DNA lesions at Ig loci via the...

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Detalles Bibliográficos
Autores principales: Caldwell, Randolph B., Braselmann, Herbert, Schoetz, Ulrike, Heuer, Steffen, Scherthan, Harry, Zitzelsberger, Horst
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931448/
https://www.ncbi.nlm.nih.gov/pubmed/27374870
http://dx.doi.org/10.1038/srep28890

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931448/
https://www.ncbi.nlm.nih.gov/pubmed/27374870
http://dx.doi.org/10.1038/srep28890

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