Structural Mechanisms and Drug Discovery Prospects of Rho GTPases

Rho GTPases regulate cellular morphology and dynamics, and some are key drivers of cancer progression. This superfamily offers attractive potential targets for therapeutic intervention, with RhoA, Rac1 and Cdc42 being prime examples. The challenges in developing agents that act on these signaling en...

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Detalles Bibliográficos
Autores principales: Smithers, Cameron C., Overduin, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931675/
https://www.ncbi.nlm.nih.gov/pubmed/27304967
http://dx.doi.org/10.3390/cells5020026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931675/
https://www.ncbi.nlm.nih.gov/pubmed/27304967
http://dx.doi.org/10.3390/cells5020026

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