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Structural Mechanisms and Drug Discovery Prospects of Rho GTPases
Rho GTPases regulate cellular morphology and dynamics, and some are key drivers of cancer progression. This superfamily offers attractive potential targets for therapeutic intervention, with RhoA, Rac1 and Cdc42 being prime examples. The challenges in developing agents that act on these signaling en...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931675/ https://www.ncbi.nlm.nih.gov/pubmed/27304967 http://dx.doi.org/10.3390/cells5020026 |