Intercellular transfer of P-glycoprotein in human blood-brain barrier endothelial cells is increased by histone deacetylase inhibitors

The blood–brain barrier (BBB) controls the entry of compounds into the brain, thereby regulating brain homeostasis. Efflux transporters such as P-glycoprotein (Pgp) significantly contribute to BBB function. Multiple signaling pathways modulate the expression and activity of Pgp in response to xenobi...

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Detalles Bibliográficos
Autores principales: Noack, Andreas, Noack, Sandra, Buettner, Manuela, Naim, Hassan Y., Löscher, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931680/
https://www.ncbi.nlm.nih.gov/pubmed/27375084
http://dx.doi.org/10.1038/srep29253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931680/
https://www.ncbi.nlm.nih.gov/pubmed/27375084
http://dx.doi.org/10.1038/srep29253

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