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IVIg attenuates complement and improves spinal cord injury outcomes in mice

OBJECTIVE: Traumatic spinal cord injury (SCI) elicits immediate neural cell death, axonal damage, and disruption of the blood–spinal cord barrier, allowing circulating immune cells and blood proteins into the spinal parenchyma. The inflammatory response to SCI involves robust complement system activ...

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Detalles Bibliográficos
Autores principales: Brennan, Faith H., Kurniawan, Nyoman D., Vukovic, Jana, Bartlett, Perry F., Käsermann, Fabian, Arumugam, Thiruma V., Basta, Milan, Ruitenberg, Marc J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931715/
https://www.ncbi.nlm.nih.gov/pubmed/27386499
http://dx.doi.org/10.1002/acn3.318