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Lack of collagen VI promotes neurodegeneration by impairing autophagy and inducing apoptosis during aging

Collagen VI is an extracellular matrix (ECM) protein with a broad distribution in different tissues and mostly deposited at the close periphery of the cell surface. Previous studies revealed that collagen VI protects neurons from the toxicity of amyloid-βpeptides and from UV-induced damage. However,...

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Detalles Bibliográficos
Autores principales: Cescon, Matilde, Chen, Peiwen, Castagnaro, Silvia, Gregorio, Ilaria, Bonaldo, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931855/
https://www.ncbi.nlm.nih.gov/pubmed/27060109
http://dx.doi.org/10.18632/aging.100924