Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells

Affinity and dose of T cell receptor (TCR) interaction with antigens govern the magnitude of CD4+ T cell responses, but questions remain regarding the quantitative translation of TCR engagement into downstream signals. We find that while the response of mouse CD4+ T cells to antigenic stimulation is...

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Detalles Bibliográficos
Autores principales: Allison, Karmel A, Sajti, Eniko, Collier, Jana G, Gosselin, David, Troutman, Ty Dale, Stone, Erica L, Hedrick, Stephen M, Glass, Christopher K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931909/
https://www.ncbi.nlm.nih.gov/pubmed/27376549
http://dx.doi.org/10.7554/eLife.10134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931909/
https://www.ncbi.nlm.nih.gov/pubmed/27376549
http://dx.doi.org/10.7554/eLife.10134

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