Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression

MicroRNAs (miRNAs) are small RNA molecules that affect cellular processes by controlling gene expression. Recent studies have shown that hypoxia downregulates Drosha and Dicer, key enzymes in miRNA biogenesis, causing a decreased pool of miRNAs in cancer, and resulting in increased tumor growth and...

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Detalles Bibliográficos
Autores principales: Rupaimoole, Rajesha, Ivan, Cristina, Yang, Da, Gharpure, Kshipra M., Wu, Sherry Y., Pecot, Chad V., Previs, Rebecca A., Nagaraja, Archana S., Armaiz-Pena, Guillermo N, McGuire, Michael, Pradeep, Sunila, Mangala, Lingegowda S., Rodriguez-Aguayo, Cristian, Huang, Li, Bar-Eli, Menashe, Zhang, Wei, Lopez-Berestein, Gabriel, Calin, George A., Sood, Anil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931989/
https://www.ncbi.nlm.nih.gov/pubmed/26725326
http://dx.doi.org/10.1038/onc.2015.492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931989/
https://www.ncbi.nlm.nih.gov/pubmed/26725326
http://dx.doi.org/10.1038/onc.2015.492

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