p19(Arf) is required for the cellular response to chronic DNA damage

The p53 tumor suppressor is a stress sensor, driving cell-cycle arrest or apoptosis in response to DNA damage or oncogenic signals. p53 activation by oncogenic signals relies on the p19(Arf) tumor suppressor, while p53 activation downstream of acute DNA damage is reported to be p19(Arf)-independent....

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Detalles Bibliográficos
Autores principales: Bieging-Rolett, Kathryn T., Johnson, Thomas M., Brady, Colleen A., Beaudry, Veronica G., Pathak, Navneeta, Han, Shuo, Attardi, Laura D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931997/
https://www.ncbi.nlm.nih.gov/pubmed/26725325
http://dx.doi.org/10.1038/onc.2015.490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931997/
https://www.ncbi.nlm.nih.gov/pubmed/26725325
http://dx.doi.org/10.1038/onc.2015.490

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