Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity

Cas9-based RNA-guided nuclease (RGN) has emerged to be a versatile method for genome editing due to the ease of construction of RGN reagents to target specific genomic sequences. The ability to control the activity of Cas9 with a high temporal resolution will facilitate tight regulation of genome ed...

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Detalles Bibliográficos
Autores principales: Nguyen, Duy P., Miyaoka, Yuichiro, Gilbert, Luke A., Mayerl, Steven J., Lee, Brian H., Weissman, Jonathan S., Conklin, Bruce R., Wells, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932181/
https://www.ncbi.nlm.nih.gov/pubmed/27363581
http://dx.doi.org/10.1038/ncomms12009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932181/
https://www.ncbi.nlm.nih.gov/pubmed/27363581
http://dx.doi.org/10.1038/ncomms12009

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