Evaluation of P-Glycoprotein Inhibitory Potential Using a Rhodamine 123 Accumulation Assay

In vitro evaluation of P-glycoprotein (P-gp) inhibitory potential is now a regulatory issue during drug development, in order to predict clinical inhibition of P-gp and subsequent drug–drug interactions. Assays for this purpose, commonly based on P-gp-expressing cell lines and digoxin as a reference...

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Detalles Bibliográficos
Autores principales: Jouan, Elodie, Le Vée, Marc, Mayati, Abdullah, Denizot, Claire, Parmentier, Yannick, Fardel, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932475/
https://www.ncbi.nlm.nih.gov/pubmed/27077878
http://dx.doi.org/10.3390/pharmaceutics8020012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932475/
https://www.ncbi.nlm.nih.gov/pubmed/27077878
http://dx.doi.org/10.3390/pharmaceutics8020012

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