IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation

Endoplasmic reticulum (ER) stress is among several pathological features that underlie β-cell failure in the development of type 1 and type 2 diabetes. Adaptor proteins in the insulin/insulin-like-growth factor-1 signaling pathways, such as insulin receptor substrate-1 (IRS1) and IRS2, differentiall...

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Detalles Bibliográficos
Autores principales: Takatani, Tomozumi, Shirakawa, Jun, Roe, Michael W., Leech, Colin A., Maier, Bernhard F., Mirmira, Raghavendra G., Kulkarni, Rohit N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932502/
https://www.ncbi.nlm.nih.gov/pubmed/27378176
http://dx.doi.org/10.1038/srep28177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932502/
https://www.ncbi.nlm.nih.gov/pubmed/27378176
http://dx.doi.org/10.1038/srep28177

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