Glycogen synthase kinase 3β suppresses polyglutamine aggregation by inhibiting Vaccinia-related kinase 2 activity

Huntington’s disease (HD) is a neurodegenerative disorder caused by an abnormal expansion of polyglutamine repeats in the N-terminal of huntingtin. The amount of aggregate-prone protein is controlled by various mechanisms, including molecular chaperones. Vaccinia-related kinase 2 (VRK2) is known to...

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Detalles Bibliográficos
Autores principales: Lee, Eunju, Ryu, Hye Guk, Kim, Sangjune, Lee, Dohyun, Jeong, Young-Hun, Kim, Kyong-Tai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932512/
https://www.ncbi.nlm.nih.gov/pubmed/27377031
http://dx.doi.org/10.1038/srep29097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932512/
https://www.ncbi.nlm.nih.gov/pubmed/27377031
http://dx.doi.org/10.1038/srep29097

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