Cargando…

Glycogen synthase kinase 3β suppresses polyglutamine aggregation by inhibiting Vaccinia-related kinase 2 activity

Huntington’s disease (HD) is a neurodegenerative disorder caused by an abnormal expansion of polyglutamine repeats in the N-terminal of huntingtin. The amount of aggregate-prone protein is controlled by various mechanisms, including molecular chaperones. Vaccinia-related kinase 2 (VRK2) is known to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Eunju, Ryu, Hye Guk, Kim, Sangjune, Lee, Dohyun, Jeong, Young-Hun, Kim, Kyong-Tai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932512/ https://www.ncbi.nlm.nih.gov/pubmed/27377031 http://dx.doi.org/10.1038/srep29097

Ejemplares similares

Autism-like behavior caused by deletion of vaccinia-related kinase 3 is improved by TrkB stimulation
por: Kang, Myung-Su, et al.
Publicado: (2017)

Protein kinase Cδ regulates vaccinia-related kinase 1 in DNA damage–induced apoptosis
por: Park, Choon-Ho, et al.
Publicado: (2011)

Glycogen Synthase Kinase-3
por: Crouch, Peter, et al.
Publicado: (2011)

Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells
por: Kim, Seong-Hoon, et al.
Publicado: (2015)

Corrigendum: Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells
por: Kim, Seong-Hoon, et al.
Publicado: (2015)

Constitutive activation of glycogen synthase kinase-3β correlates with better prognosis and cyclin-dependent kinase inhibitors in human gastric cancer
por: Cho, Yu Jin, et al.
Publicado: (2010)

Interactomes of Glycogen Synthase Kinase-3 Isoforms
por: Cormier, Kevin W., et al.
Publicado: (2023)

Luteolin Suppresses Cancer Cell Proliferation by Targeting Vaccinia-Related Kinase 1
por: Kim, Ye Seul, et al.
Publicado: (2014)

Glycogen synthase kinase 3β in tumorigenesis and oncotherapy
por: He, Rui, et al.
Publicado: (2020)

Therapeutic Approaches for Inhibition of Protein Aggregation in Huntington's Disease
por: Kim, Sangjune, et al.
Publicado: (2014)

Glycogen synthase kinase 3β in Toll-like receptor signaling
por: Ko, Ryeojin, et al.
Publicado: (2016)

Glycogen synthase kinase 3β and cyclin D1 expression in cervical carcinogenesis
por: Park, Hyunsoo, et al.
Publicado: (2016)

Defective folliculogenesis in female mice lacking Vaccinia-related kinase 1
por: Kim, Jinkyung, et al.
Publicado: (2012)

Phylogenetic diversification of glycogen synthase kinase 3/SHAGGY-like kinase genes in plants
por: Yoo, Mi-Jeong, et al.
Publicado: (2006)

Identification and characterization of two wheat Glycogen Synthase Kinase 3/ SHAGGY-like kinases
por: Bittner, Thomas, et al.
Publicado: (2013)

Treadmill exercise decreases incidence of Alzheimer’s disease by suppressing glycogen synthase kinase-3β expression in streptozotocin-induced diabetic rats
por: Kim, Dae-Young, et al.
Publicado: (2015)

Glycogen Synthase Kinase-3 in the Etiology and Treatment of Mood Disorders
por: Jope, Richard Scott
Publicado: (2011)

Glycogen Synthase Kinase-3 is an Intermediate Modulator of Serotonin Neurotransmission
por: Polter, Abigail M., et al.
Publicado: (2011)

Glycogen Synthase Kinase-3 Is Required for Efficient Dictyostelium Chemotaxis
por: Teo, Regina, et al.
Publicado: (2010)

The Effects of Glycogen Synthase Kinase-3beta in Serotonin Neurons
por: Zhou, Wenjun, et al.
Publicado: (2012)

Glycogen Synthase Kinase 3β in Cancer Biology and Treatment
por: Domoto, Takahiro, et al.
Publicado: (2020)

Glycogen Synthase Kinase 3: Ion Channels, Plasticity, and Diseases
por: Marosi, Mate, et al.
Publicado: (2022)

The role of glycogen synthase kinase 3 beta in neurodegenerative diseases
por: Yu, Honglu, et al.
Publicado: (2023)

Glycogen synthase kinase 3 drives thymocyte egress by suppressing β-catenin activation of Akt
por: Liu, Chenfeng, et al.
Publicado: (2021)

Regenerative potential of targeting glycogen synthase kinase-3 signaling in neural tissues
por: Jung, Eui-Man, et al.
Publicado: (2015)

Deletion of Glycogen Synthase Kinase 3 Beta Reprograms NK Cell Metabolism
por: Pereira, Marcelo S. F., et al.
Publicado: (2023)

Intracellular Aggregation of Polypeptides with Expanded Polyglutamine Domain Is Stimulated by Stress-Activated Kinase Mekk1
por: Meriin, Anatoli B., et al.
Publicado: (2001)

Mitogen-activated protein kinase phosphatase 2 regulates histone H3 phosphorylation via interaction with vaccinia-related kinase 1
por: Jeong, Min-Woo, et al.
Publicado: (2013)

Lithium and GADL1 regulate glycogen synthase kinase-3 activity to modulate KCTD12 expression
por: Wu, Tai-Na, et al.
Publicado: (2019)

Lithium ameliorates rat spinal cord injury by suppressing glycogen synthase kinase-3β and activating heme oxygenase-1
por: Kim, Yonghoon, et al.
Publicado: (2017)

Inhibition of Glycogen Synthase Kinase-3β Attenuates Glucocorticoid-Induced Suppression of Myogenic Differentiation In Vitro
por: Ma, Zhenyu, et al.
Publicado: (2014)

Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral Sclerosis
por: Koh, Seong-Ho, et al.
Publicado: (2011)

Antidiabetic and vasoprotective activity of lithium: Role of glycogen synthase kinase-3
por: Kanzariya, Nilesh R., et al.
Publicado: (2011)

Functional Implications of Glycogen Synthase Kinase-3-Mediated Tau Phosphorylation
por: Hanger, Diane P., et al.
Publicado: (2011)

Regulation by Glycogen Synthase Kinase-3 of Inflammation and T Cells in CNS Diseases
por: Beurel, Eléonore
Publicado: (2011)

Emerging Roles of Glycogen Synthase Kinase 3 in the Treatment of Brain Tumors
por: Mills, Caroline N., et al.
Publicado: (2011)

Association of glycogen synthase kinase-3β with Parkinson’s disease (Review)
por: LI, DA-WEI, et al.
Publicado: (2014)

Aberrant glycogen synthase kinase 3β in the development of pancreatic cancer
por: Shimasaki, Takeo, et al.
Publicado: (2012)

Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and Imaging
por: Pandey, Mukesh K., et al.
Publicado: (2016)

Glycogen synthase kinase-3β modulation of glucocorticoid responsiveness in COPD
por: Ngkelo, Anta, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_4t4bc5apbu2dh6hlcv6bojon7s