The 14th Ile residue is essential for Leptin function in regulating energy homeostasis in rat

LEPTIN (LEP) is a circulating hormone released primarily from white adipocytes and is crucial for regulating satiety and energy homeostasis in humans and animals. Using the CRISPR technology, we created a set of Lep mutant rats that carry either null mutations or a deletion of the 14(th) Ile (LEP(∆I...

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Detalles Bibliográficos
Autores principales: Xu, Shuyang, Zhu, Xianmin, Li, Hong, Hu, Youtian, Zhou, Jinping, He, Di, Feng, Yun, Lu, Lina, Du, Guizhen, Hu, Youjin, Liu, Tiancheng, Wang, Zhen, Ding, Guohui, Chen, Jiayu, Gao, Shaorong, Wu, Fang, Xue, Zhigang, Li, Yixue, Fan, Guoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932527/
https://www.ncbi.nlm.nih.gov/pubmed/27378381
http://dx.doi.org/10.1038/srep28508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932527/
https://www.ncbi.nlm.nih.gov/pubmed/27378381
http://dx.doi.org/10.1038/srep28508

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