Search for Potent and Selective Aurora A Inhibitors Based on General Ser/Thr Kinase Pharmacophore Model

Based on the data for compounds known from the literature to be active against various types of Ser/Thr kinases, a general pharmachophore model for these types of kinases was developed. The search for the molecules fitting to this pharmacophore among the ASINEX proprietary library revealed a number...

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Detalles Bibliográficos
Autores principales: Vasilevich, Natalya I., Tatarskiy, Victor V., Aksenova, Elena A., Kazyulkin, Denis N., Afanasyev, Ilya I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932537/
https://www.ncbi.nlm.nih.gov/pubmed/27089349
http://dx.doi.org/10.3390/ph9020019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932537/
https://www.ncbi.nlm.nih.gov/pubmed/27089349
http://dx.doi.org/10.3390/ph9020019

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