Cargando…

Improved Aptamers for the Diagnosis and Potential Treatment of HER2-Positive Cancer

Aptamers provide a potential source of alternative targeting molecules for existing antibody diagnostics and therapeutics. In this work, we selected novel DNA aptamers targeting the HER2 receptor by an adherent whole-cell SELEX approach. Individual aptamers were identified by next generation sequenc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gijs, Marlies, Penner, Gregory, Blackler, Garth B., Impens, Nathalie R.E.N., Baatout, Sarah, Luxen, André, Aerts, An M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932547/ https://www.ncbi.nlm.nih.gov/pubmed/27213406 http://dx.doi.org/10.3390/ph9020029

Ejemplares similares

Targeted Radionuclide Therapy with A (177)Lu-labeled Anti-HER2 Nanobody
por: D'Huyvetter, Matthias, et al.
Publicado: (2014)

Development of novel aptamers for low-density lipoprotein particle quantification
por: Klapak, Daniel, et al.
Publicado: (2018)

Novel HER2 Aptamer Selectively Delivers Cytotoxic Drug to HER2-positive Breast Cancer Cells in Vitro
por: Liu, Zhe, et al.
Publicado: (2012)

Synergistic Targeting HER2 and EGFR with Bivalent Aptamer-siRNA Chimera Efficiently Inhibits HER2-Positive Tumor Growth
por: Xue, Lu, et al.
Publicado: (2018)

Aptamers as biomarkers for neurological disorders. Proof of concept in transgenic mice
por: Lecocq, Soizic, et al.
Publicado: (2018)

Copolymer micelles function as pH-responsive nanocarriers to enhance the cytotoxicity of a HER2 aptamer in HER2-positive breast cancer cells
por: Shen, Yinxing, et al.
Publicado: (2018)

Pathological effects of ionizing radiation: endothelial activation and dysfunction
por: Baselet, Bjorn, et al.
Publicado: (2018)

The role of connexin proteins and their channels in radiation-induced atherosclerosis
por: Ramadan, Raghda, et al.
Publicado: (2021)

Correction to: The role of connexin proteins and their channels in radiation-induced atherosclerosis
por: Ramadan, Raghda, et al.
Publicado: (2021)

Potential applications of aptamers in veterinary science
por: Niederlender, Solène, et al.
Publicado: (2021)

Aptamer–drug conjugate: targeted delivery of doxorubicin in a HER3 aptamer-functionalized liposomal delivery system reduces cardiotoxicity
por: Dou, Xiao-qian, et al.
Publicado: (2018)

PET imaging of HER2 expression with an (18)F-fluoride labeled aptamer
por: Kim, Hyun Jeong, et al.
Publicado: (2019)

Development of HER2-Specific Aptamer-Drug Conjugate for Breast Cancer Therapy
por: Jeong, Hwa Yeon, et al.
Publicado: (2020)

Aptamer: A potential oligonucleotide nanomedicine in the diagnosis and treatment of hepatocellular carcinoma
por: Ladju, Rusdina Bte, et al.
Publicado: (2017)

Screening of aptamers and their potential application in targeted diagnosis and therapy of liver cancer
por: Zhang, Guo-Qing, et al.
Publicado: (2019)

Cardiovascular diseases related to ionizing radiation: The risk of low-dose exposure (Review)
por: Baselet, Bjorn, et al.
Publicado: (2016)

Aptamer-based biosensors for the diagnosis of sepsis
por: Liu, Lubin, et al.
Publicado: (2021)

Aptamer-modified Magnetic Nanosensitizer for in vivo MR imaging of HER2-expressing Cancer
por: Heo, Dan, et al.
Publicado: (2018)

Correction: Aptamer: A potential oligonucleotide nanomedicine in the diagnosis and treatment of hepatocellular carcinoma
por: Ladju, Rusdina Bte, et al.
Publicado: (2018)

Targeting EGFR/HER2/HER3 with a Three-in-One Aptamer-siRNA Chimera Confers Superior Activity against HER2(+) Breast Cancer
por: Yu, Xiaolin, et al.
Publicado: (2017)

The effect of HLA-DRB1*04:01 on a mouse model of atherosclerosis
por: Blackler, Garth, et al.
Publicado: (2023)

Radiation-induced cardiovascular disease: an overlooked role for DNA methylation?
por: Sallam, Magy, et al.
Publicado: (2021)

Aptamers and Glioblastoma: Their Potential Use for Imaging and Therapeutic Applications
por: Hays, Emma M., et al.
Publicado: (2017)

The Evolution of Targeted Radionuclide Diagnosis of HER2-Positive Breast Cancer
por: Bragina, O. D., et al.
Publicado: (2022)

Elimination of HER3-expressing breast cancer cells using aptamer-siRNA chimeras
por: Nachreiner, Inga, et al.
Publicado: (2019)

The effect of sex on immune responses to a homocitrullinated peptide in the DR4-transgenic mouse model of Rheumatoid Arthritis
por: Cairns, Ewa, et al.
Publicado: (2020)

Current Advances in Aptamers for Cancer Diagnosis and Therapy
por: Hori, Shin-ichiro, et al.
Publicado: (2018)

Aptamers: Promising Tools for Cancer Diagnosis and Therapy
por: Cerchia, Laura
Publicado: (2018)

DNA Aptamers in the Diagnosis and Treatment of Human Diseases
por: Zhu, Qinchang, et al.
Publicado: (2015)

Aptamers and Their Significant Role in Cancer Therapy and Diagnosis
por: Joy Sebastian Prakash,, et al.
Publicado: (2015)

Aptamers: An Emerging Tool for Diagnosis and Therapeutics in Tuberculosis
por: Srivastava, Shruti, et al.
Publicado: (2021)

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
por: Liu, Ran, et al.
Publicado: (2020)

Delivery of chemo-sensitizing siRNAs to HER2(+)-breast cancer cells using RNA aptamers
por: Thiel, Kristina W., et al.
Publicado: (2012)

Development of RNA aptamers as molecular probes for HER2(+) breast cancer study using cell-SELEX
por: Moosavian, Seyedeh Alia, et al.
Publicado: (2015)

A dual-functional HER2 aptamer-conjugated, pH-activated mesoporous silica nanocarrier-based drug delivery system provides in vitro synergistic cytotoxicity in HER2-positive breast cancer cells
por: Shen, Yinxing, et al.
Publicado: (2019)

Pregnancies in young women with diagnosis and treatment of HER2-positive breast cancer
por: Lambertini, Matteo, et al.
Publicado: (2019)

Development, screening, and analysis of DNA aptamer libraries potentially useful for diagnosis and passive immunity of arboviruses
por: Bruno, John G, et al.
Publicado: (2012)

Aptamers: Active Targeting Ligands for Cancer Diagnosis and Therapy
por: Wu, Xu, et al.
Publicado: (2015)

Nucleic acid aptamer-based methods for diagnosis of infections
por: Park, Ki Soo
Publicado: (2018)

Aptamers and Antisense Oligonucleotides for Diagnosis and Treatment of Hematological Diseases
por: Giudice, Valentina, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_pph8vakma0roilgc1nufph7eh9