Transnasal delivery of human A-beta peptides elicits impaired learning and memory performance in wild type mice

BACKGROUND: Murine models of Alzheimer’s disease (AD) are mainly based on overexpression of pathologic amyloid precursor protein and/or presenilins. Those genes resemble underlying cause of early onset type of AD while about 99 % of all human cases are to be characterized as sporadic, late onset. Ap...

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Detalles Bibliográficos
Autores principales: Endres, Kristina, Reinhardt, Sven, Geladaris, Anastasia, Knies, Julia, Grimm, Marcus, Hartmann, Tobias, Schmitt, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932715/
https://www.ncbi.nlm.nih.gov/pubmed/27377996
http://dx.doi.org/10.1186/s12868-016-0280-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932715/
https://www.ncbi.nlm.nih.gov/pubmed/27377996
http://dx.doi.org/10.1186/s12868-016-0280-9

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