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Transnasal delivery of human A-beta peptides elicits impaired learning and memory performance in wild type mice
BACKGROUND: Murine models of Alzheimer’s disease (AD) are mainly based on overexpression of pathologic amyloid precursor protein and/or presenilins. Those genes resemble underlying cause of early onset type of AD while about 99 % of all human cases are to be characterized as sporadic, late onset. Ap...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932715/ https://www.ncbi.nlm.nih.gov/pubmed/27377996 http://dx.doi.org/10.1186/s12868-016-0280-9 |