Dynamic Regulation of Quaternary Organization of the M(1) Muscarinic Receptor by Subtype-selective Antagonist Drugs

Although rhodopsin-like G protein-coupled receptors can exist as both monomers and non-covalently associated dimers/oligomers, the steady-state proportion of each form and whether this is regulated by receptor ligands are unknown. Herein we address these topics for the M(1) muscarinic acetylcholine...

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Detalles Bibliográficos
Autores principales: Pediani, John D., Ward, Richard J., Godin, Antoine G., Marsango, Sara, Milligan, Graeme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933229/
https://www.ncbi.nlm.nih.gov/pubmed/27080256
http://dx.doi.org/10.1074/jbc.M115.712562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933229/
https://www.ncbi.nlm.nih.gov/pubmed/27080256
http://dx.doi.org/10.1074/jbc.M115.712562

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