Propionate Increases Hepatic Pyruvate Cycling and Anaplerosis and Alters Mitochondrial Metabolism

In mammals, pyruvate kinase (PK) plays a key role in regulating the balance between glycolysis and gluconeogenesis; however, in vivo regulation of PK flux by gluconeogenic hormones and substrates is poorly understood. To this end, we developed a novel NMR-liquid chromatography/tandem-mass spectromet...

Descripción completa

Detalles Bibliográficos
Autores principales: Perry, Rachel J., Borders, Candace B., Cline, Gary W., Zhang, Xian-Man, Alves, Tiago C., Petersen, Kitt Falk, Rothman, Douglas L., Kibbey, Richard G., Shulman, Gerald I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933266/
https://www.ncbi.nlm.nih.gov/pubmed/27002151
http://dx.doi.org/10.1074/jbc.M116.720631

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933266/
https://www.ncbi.nlm.nih.gov/pubmed/27002151
http://dx.doi.org/10.1074/jbc.M116.720631

Ejemplares similares