Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner

The microtubule-associated protein tau has a critical role in Alzheimer disease and related tauopathies. There is accumulating evidence that tau aggregates spread and replicate in a prion-like manner, with the uptake of pathological tau seeds causing misfolding and aggregation of monomeric tau in re...

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Detalles Bibliográficos
Autores principales: Polanco, Juan Carlos, Scicluna, Benjamin James, Hill, Andrew Francis, Götz, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Neurobiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933440/
https://www.ncbi.nlm.nih.gov/pubmed/27030011
http://dx.doi.org/10.1074/jbc.M115.709485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933440/
https://www.ncbi.nlm.nih.gov/pubmed/27030011
http://dx.doi.org/10.1074/jbc.M115.709485

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