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Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner

The microtubule-associated protein tau has a critical role in Alzheimer disease and related tauopathies. There is accumulating evidence that tau aggregates spread and replicate in a prion-like manner, with the uptake of pathological tau seeds causing misfolding and aggregation of monomeric tau in re...

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Detalles Bibliográficos
Autores principales:	Polanco, Juan Carlos, Scicluna, Benjamin James, Hill, Andrew Francis, Götz, Jürgen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2016
Materias:	Neurobiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933440/ https://www.ncbi.nlm.nih.gov/pubmed/27030011 http://dx.doi.org/10.1074/jbc.M115.709485

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