NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease

NGF has been implicated in forebrain neuroprotection from amyloidogenesis and Alzheimer's disease (AD). However, the underlying molecular mechanisms are still poorly understood. Here, we investigated the role of NGF signalling in the metabolism of amyloid precursor protein (APP) in forebrain ne...

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Detalles Bibliográficos
Autores principales: Triaca, Viviana, Sposato, Valentina, Bolasco, Giulia, Ciotti, Maria Teresa, Pelicci, Piergiuseppe, Bruni, Amalia C., Cupidi, Chiara, Maletta, Raffaele, Feligioni, Marco, Nisticò, Robert, Canu, Nadia, Calissano, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933663/
https://www.ncbi.nlm.nih.gov/pubmed/27076121
http://dx.doi.org/10.1111/acel.12473

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933663/
https://www.ncbi.nlm.nih.gov/pubmed/27076121
http://dx.doi.org/10.1111/acel.12473

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