Inhibition of neutrophil superoxide generation by shikonin is associated with suppression of cellular Ca(2+) fluxes

Shikonin, an anti-inflammatory compound of “Shikon”, inhibits the neutrophil superoxide (O(2)(•−)) generation by NADPH oxidase 2 (Nox2); however, the mechanisms of how shikonin affects Nox2 activity remained unclear. We aimed to elucidate the relationship between the inhibition of Nox2 activity and...

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Detalles Bibliográficos
Autores principales: Kazumura, Kimiko, Yoshida, Lucia Satiko, Hara, Akiko, Tsuchiya, Hiroshi, Morishita, Naokazu, Kawagishi, Hirokazu, Kakegawa, Tomohito, Yuda, Yasukatsu, Takano-Ohmuro, Hiromi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933695/
https://www.ncbi.nlm.nih.gov/pubmed/27499572
http://dx.doi.org/10.3164/jcbn.16-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933695/
https://www.ncbi.nlm.nih.gov/pubmed/27499572
http://dx.doi.org/10.3164/jcbn.16-4

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