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Inhibition of neutrophil superoxide generation by shikonin is associated with suppression of cellular Ca(2+) fluxes
Shikonin, an anti-inflammatory compound of “Shikon”, inhibits the neutrophil superoxide (O(2)(•−)) generation by NADPH oxidase 2 (Nox2); however, the mechanisms of how shikonin affects Nox2 activity remained unclear. We aimed to elucidate the relationship between the inhibition of Nox2 activity and...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
the Society for Free Radical Research Japan
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933695/ https://www.ncbi.nlm.nih.gov/pubmed/27499572 http://dx.doi.org/10.3164/jcbn.16-4 |