Thioredoxin interacting protein (TXNIP) regulates tubular autophagy and mitophagy in diabetic nephropathy through the mTOR signaling pathway

Hyperglycemia upregulates thioredoxin interacting protein (TXNIP) expression, which in turn induces ROS production, inflammatory and fibrotic responses in the diabetic kidney. Dysregulation of autophagy contributes to the development of diabetic nephropathy. However, the interaction of TXNIP with au...

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Detalles Bibliográficos
Autores principales: Huang, Chunling, Zhang, Yuan, Kelly, Darren J., Tan, Christina Y. R., Gill, Anthony, Cheng, Delfine, Braet, Filip, Park, Jin-Sung, Sue, Carolyn M., Pollock, Carol A., Chen, Xin-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933928/
https://www.ncbi.nlm.nih.gov/pubmed/27381856
http://dx.doi.org/10.1038/srep29196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933928/
https://www.ncbi.nlm.nih.gov/pubmed/27381856
http://dx.doi.org/10.1038/srep29196

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