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Single-cell genome-wide bisulfite sequencing uncovers extensive heterogeneity in the mouse liver methylome
BACKGROUND: Transmission fidelity of CpG DNA methylation patterns is not foolproof, with error rates from less than 1 to well over 10 % per CpG site, dependent on preservation of the methylated or unmethylated state and the type of sequence. This suggests a fairly high chance of errors. However, the...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934005/ https://www.ncbi.nlm.nih.gov/pubmed/27380908 http://dx.doi.org/10.1186/s13059-016-1011-3 |