Mutations in the Schmallenberg Virus Gc Glycoprotein Facilitate Cellular Protein Synthesis Shutoff and Restore Pathogenicity of NSs Deletion Mutants in Mice

Serial passage of viruses in cell culture has been traditionally used to attenuate virulence and identify determinants of viral pathogenesis. In a previous study, we found that a strain of Schmallenberg virus (SBV) serially passaged in tissue culture (termed SBVp32) unexpectedly displayed increased...

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Detalles Bibliográficos
Autores principales: Varela, Mariana, Pinto, Rute Maria, Caporale, Marco, Piras, Ilaria M., Taggart, Aislynn, Seehusen, Frauke, Hahn, Kerstin, Janowicz, Anna, de Souza, William Marciel, Baumgärtner, Wolfgang, Shi, Xiaohong, Palmarini, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Pathogenesis and Immunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934738/
https://www.ncbi.nlm.nih.gov/pubmed/26984728
http://dx.doi.org/10.1128/JVI.00424-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934738/
https://www.ncbi.nlm.nih.gov/pubmed/26984728
http://dx.doi.org/10.1128/JVI.00424-16

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