Cargando…

Mutations in the Schmallenberg Virus Gc Glycoprotein Facilitate Cellular Protein Synthesis Shutoff and Restore Pathogenicity of NSs Deletion Mutants in Mice

Serial passage of viruses in cell culture has been traditionally used to attenuate virulence and identify determinants of viral pathogenesis. In a previous study, we found that a strain of Schmallenberg virus (SBV) serially passaged in tissue culture (termed SBVp32) unexpectedly displayed increased...

Descripción completa

Detalles Bibliográficos
Autores principales:	Varela, Mariana, Pinto, Rute Maria, Caporale, Marco, Piras, Ilaria M., Taggart, Aislynn, Seehusen, Frauke, Hahn, Kerstin, Janowicz, Anna, de Souza, William Marciel, Baumgärtner, Wolfgang, Shi, Xiaohong, Palmarini, Massimo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2016
Materias:	Pathogenesis and Immunity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934738/ https://www.ncbi.nlm.nih.gov/pubmed/26984728 http://dx.doi.org/10.1128/JVI.00424-16

Ejemplares similares

NSs protein of Schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery
por: Barry, Gerald, et al.
Publicado: (2014)

Multiple Genome Segments Determine Virulence of Bluetongue Virus Serotype 8
por: Janowicz, Anna, et al.
Publicado: (2015)

Virus and Host Factors Affecting the Clinical Outcome of Bluetongue Virus Infection
por: Caporale, Marco, et al.
Publicado: (2014)

The P681H Mutation in the Spike Glycoprotein of the Alpha Variant of SARS-CoV-2 Escapes IFITM Restriction and Is Necessary for Type I Interferon Resistance
por: Lista, Maria Jose, et al.
Publicado: (2022)

Glycoprotein B Cleavage Is Important for Murid Herpesvirus 4 To Infect Myeloid Cells
por: Glauser, Daniel L., et al.
Publicado: (2013)

Ability of the Encephalitic Arbovirus Semliki Forest Virus To Cross the Blood-Brain Barrier Is Determined by the Charge of the E2 Glycoprotein
por: Ferguson, Mhairi C., et al.
Publicado: (2015)

Testicular Degeneration and Infertility following Arbovirus Infection
por: Puggioni, Giantonella, et al.
Publicado: (2018)

The Unique Glycosylation at Position 986 on the E2 Glycoprotein of Classical Swine Fever Virus Is Responsible for Viral Attenuation and Protection against Lethal Challenge
por: Li, Yongfeng, et al.
Publicado: (2022)

A Novel Antigenic Site Spanning Domains I and III of the Zika Virus Envelope Glycoprotein Is the Target of Strongly Neutralizing Human Monoclonal Antibodies
por: Graham, Stephen D., et al.
Publicado: (2021)

Nonstructural Protein NSs of Schmallenberg Virus Is Targeted to the Nucleolus and Induces Nucleolar Disorganization
por: Gouzil, Julie, et al.
Publicado: (2016)

PRRSV Infection Induces Gasdermin D-Driven Pyroptosis of Porcine Alveolar Macrophages through NLRP3 Inflammasome Activation
por: He, Sheng, et al.
Publicado: (2022)

Schmallenberg Virus Pathogenesis, Tropism and Interaction with the Innate Immune System of the Host
por: Varela, Mariana, et al.
Publicado: (2013)

A Single Amino Acid Substitution in the Novel H7N9 Influenza A Virus NS1 Protein Increases CPSF30 Binding and Virulence
por: Ayllon, Juan, et al.
Publicado: (2014)

Impact of HLA Selection Pressure on HIV Fitness at a Population Level in Mexico and Barbados
por: Juarez-Molina, Claudia I., et al.
Publicado: (2014)

Acute-Phase CD8 T Cell Responses That Select for Escape Variants Are Needed to Control Live Attenuated Simian Immunodeficiency Virus
por: Harris, Max, et al.
Publicado: (2013)

High Production Rates Sustain In Vivo Levels of PD-1(high) Simian Immunodeficiency Virus-Specific CD8 T Cells in the Face of Rapid Clearance
por: Petrovas, Constantinos, et al.
Publicado: (2013)

Regulatory T Cells Prevent Th2 Immune Responses and Pulmonary Eosinophilia during Respiratory Syncytial Virus Infection in Mice
por: Durant, Lydia R., et al.
Publicado: (2013)

Herpes Simplex Virus 1 Targets the Murine Olfactory Neuroepithelium for Host Entry
por: Shivkumar, Maitreyi, et al.
Publicado: (2013)

Immunosuppression Facilitates the Reactivation of Latent Papillomavirus Infections
por: Maglennon, G. A., et al.
Publicado: (2014)

Delayed Sequelae of Neonatal Respiratory Syncytial Virus Infection Are Dependent on Cells of the Innate Immune System
por: Harker, James A., et al.
Publicado: (2014)

Vaccinia Virus Inhibits NF-κB-Dependent Gene Expression Downstream of p65 Translocation
por: Sumner, Rebecca P., et al.
Publicado: (2014)

Respiratory Syncytial Virus Infection, TLR3 Ligands, and Proinflammatory Cytokines Induce CD161 Ligand LLT1 Expression on the Respiratory Epithelium
por: Satkunanathan, Stifani, et al.
Publicado: (2014)

BAFF Receptor Deficiency Limits Gammaherpesvirus Infection
por: Frederico, Bruno, et al.
Publicado: (2014)

Peptide-Dependent Recognition of HLA-B*57:01 by KIR3DS1
por: O'Connor, Geraldine M., et al.
Publicado: (2015)

Tick Saliva Enhances Powassan Virus Transmission to the Host, Influencing Its Dissemination and the Course of Disease
por: Hermance, Meghan E., et al.
Publicado: (2015)

Expanding Regulatory T Cells Alleviates Chikungunya Virus-Induced Pathology in Mice
por: Lee, Wendy W. L., et al.
Publicado: (2015)

Caribbean and La Réunion Chikungunya Virus Isolates Differ in Their Capacity To Induce Proinflammatory Th1 and NK Cell Responses and Acute Joint Pathology
por: Teo, Teck-Hui, et al.
Publicado: (2015)

Glycine at Position 622 in PB1 Contributes to the Virulence of H5N1 Avian Influenza Virus in Mice
por: Feng, Xiaoxiao, et al.
Publicado: (2016)

Tetramer Enrichment Reveals the Presence of Phenotypically Diverse Hepatitis C Virus-Specific CD8(+) T Cells in Chronic Infection
por: Nitschke, Katja, et al.
Publicado: (2014)

Complement Opsonization Promotes Herpes Simplex Virus 2 Infection of Human Dendritic Cells
por: Crisci, Elisa, et al.
Publicado: (2016)

The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases
por: Kühn, Nora, et al.
Publicado: (2016)

Primary B Lymphocytes Infected with Kaposi's Sarcoma-Associated Herpesvirus Can Be Expanded In Vitro and Are Recognized by LANA-Specific CD4(+) T Cells
por: Nicol, Samantha M., et al.
Publicado: (2016)

Lymphatic Dissemination of Simian Immunodeficiency Virus after Penile Inoculation
por: Ma, Zhong-Min, et al.
Publicado: (2016)

Two Novel DNAs That Enhance Symptoms and Overcome CMD2 Resistance to Cassava Mosaic Disease
por: Ndunguru, Joseph, et al.
Publicado: (2016)

Leukocyte Immunoglobulin-Like Receptor 1-Expressing Human Natural Killer Cell Subsets Differentially Recognize Isolates of Human Cytomegalovirus through the Viral Major Histocompatibility Complex Class I Homolog UL18
por: Chen, Kevin C., et al.
Publicado: (2016)

Lipopolysaccharide and Tumor Necrosis Factor Alpha Inhibit Interferon Signaling in Hepatocytes by Increasing Ubiquitin-Like Protease 18 (USP18) Expression
por: MacParland, Sonya A., et al.
Publicado: (2016)

Chicken and Duck Myotubes Are Highly Susceptible and Permissive to Influenza Virus Infection
por: Baquero-Perez, Belinda, et al.
Publicado: (2014)

Protection from Severe Influenza Virus Infections in Mice Carrying the Mx1 Influenza Virus Resistance Gene Strongly Depends on Genetic Background
por: Shin, Dai-Lun, et al.
Publicado: (2015)

Inhibition of Histone Deacetylase Activity Aggravates Coxsackievirus B3-Induced Myocarditis by Promoting Viral Replication and Myocardial Apoptosis
por: Zhou, Lei, et al.
Publicado: (2015)

Defensive Perimeter in the Central Nervous System: Predominance of Astrocytes and Astrogliosis during Recovery from Varicella-Zoster Virus Encephalitis
por: Carpenter, John E., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_4j7eh325qr4f07dj6u1iudkp1k