Axonal Dysfunction Precedes Motor Neuronal Death in Amyotrophic Lateral Sclerosis

Wide-spread fasciculations are a characteristic feature in amyotrophic lateral sclerosis (ALS), suggesting motor axonal hyperexcitability. Previous excitability studies have shown increased nodal persistent sodium conductances and decreased potassium currents in motor axons of ALS patients, both of...

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Detalles Bibliográficos
Autores principales: Iwai, Yuta, Shibuya, Kazumoto, Misawa, Sonoko, Sekiguchi, Yukari, Watanabe, Keisuke, Amino, Hiroshi, Kuwabara, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934877/
https://www.ncbi.nlm.nih.gov/pubmed/27383069
http://dx.doi.org/10.1371/journal.pone.0158596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934877/
https://www.ncbi.nlm.nih.gov/pubmed/27383069
http://dx.doi.org/10.1371/journal.pone.0158596

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