Cargando…

Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against Cisplatin-induced expression of p53, MDM2, p21(Waf1/Cip1), and Caspase-9/-3 activation

The leucine-rich repeat containing 8A (LRRC8A) protein is an essential component of the volume-sensitive organic anion channel (VSOAC), and using pharmacological anion channel inhibitors (NS3728, DIDS) and LRRC8A siRNA we have investigated its role in development of Cisplatin resistance in human ova...

Descripción completa

Detalles Bibliográficos
Autores principales: Sørensen, Belinda Halling, Nielsen, Dorthe, Thorsteinsdottir, Unnur Arna, Hoffmann, Else Kay, Lambert, Ian Henry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935196/
https://www.ncbi.nlm.nih.gov/pubmed/26984736
http://dx.doi.org/10.1152/ajpcell.00256.2015