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Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against Cisplatin-induced expression of p53, MDM2, p21(Waf1/Cip1), and Caspase-9/-3 activation

The leucine-rich repeat containing 8A (LRRC8A) protein is an essential component of the volume-sensitive organic anion channel (VSOAC), and using pharmacological anion channel inhibitors (NS3728, DIDS) and LRRC8A siRNA we have investigated its role in development of Cisplatin resistance in human ova...

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Detalles Bibliográficos
Autores principales:	Sørensen, Belinda Halling, Nielsen, Dorthe, Thorsteinsdottir, Unnur Arna, Hoffmann, Else Kay, Lambert, Ian Henry
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Physiological Society 2016
Materias:	Call for Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935196/ https://www.ncbi.nlm.nih.gov/pubmed/26984736 http://dx.doi.org/10.1152/ajpcell.00256.2015

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