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COG lobe B sub-complex engages v-SNARE GS15 and functions via regulated interaction with lobe A sub-complex

The conserved oligomeric Golgi (COG) complex is a peripheral membrane protein complex which orchestrates tethering of intra-Golgi vesicles. We found that COG1-4 (lobe A) and 5–8 (lobe B) protein assemblies are present as independent sub-complexes on cell membranes. Super-resolution microscopy demons...

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Detalles Bibliográficos
Autores principales: Willett, Rose, Blackburn, Jessica Bailey, Climer, Leslie, Pokrovskaya, Irina, Kudlyk, Tetyana, Wang, Wei, Lupashin, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935880/
https://www.ncbi.nlm.nih.gov/pubmed/27385402
http://dx.doi.org/10.1038/srep29139