HCV RNA Activates APCs via TLR7/TLR8 While Virus Selectively Stimulates Macrophages Without Inducing Antiviral Responses

The innate and adaptive immune systems fail to control HCV infection in the majority of infected individuals. HCV is an ssRNA virus, which suggests a role for Toll-like receptors (TLRs) 7 and 8 in initiating the anti-viral response. Here we demonstrate that HCV genomic RNA harbours specific sequence...

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Detalles Bibliográficos
Autores principales: Zhang, Yuwei, El-Far, Mohamed, Dupuy, Franck P., Abdel-Hakeem, Mohamed S., He, Zhong, Procopio, Francesco Andrea, Shi, Yu, Haddad, Elias K., Ancuta, Petronela, Sekaly, Rafick-Pierre, Said, Elias A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935957/
https://www.ncbi.nlm.nih.gov/pubmed/27385120
http://dx.doi.org/10.1038/srep29447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935957/
https://www.ncbi.nlm.nih.gov/pubmed/27385120
http://dx.doi.org/10.1038/srep29447

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