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HCV RNA Activates APCs via TLR7/TLR8 While Virus Selectively Stimulates Macrophages Without Inducing Antiviral Responses
The innate and adaptive immune systems fail to control HCV infection in the majority of infected individuals. HCV is an ssRNA virus, which suggests a role for Toll-like receptors (TLRs) 7 and 8 in initiating the anti-viral response. Here we demonstrate that HCV genomic RNA harbours specific sequence...
Autores principales: | Zhang, Yuwei, El-Far, Mohamed, Dupuy, Franck P., Abdel-Hakeem, Mohamed S., He, Zhong, Procopio, Francesco Andrea, Shi, Yu, Haddad, Elias K., Ancuta, Petronela, Sekaly, Rafick-Pierre, Said, Elias A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935957/ https://www.ncbi.nlm.nih.gov/pubmed/27385120 http://dx.doi.org/10.1038/srep29447 |
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