A Hypertension-Associated tRNA(Ala) Mutation Alters tRNA Metabolism and Mitochondrial Function

In this report, we investigated the pathophysiology of a novel hypertension-associated mitochondrial tRNA(Ala) 5655A → G (m.5655A → G) mutation. The destabilization of a highly conserved base pairing (A1-U72) at the aminoacyl acceptor stem by an m.5655A → G mutation altered the tRNA(Ala) function. A...

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Detalles Bibliográficos
Autores principales: Jiang, Pingping, Wang, Meng, Xue, Ling, Xiao, Yun, Yu, Jialing, Wang, Hui, Yao, Juan, Liu, Hao, Peng, Yanyan, Liu, Hanqing, Li, Haiying, Chen, Ye, Guan, Min-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936059/
https://www.ncbi.nlm.nih.gov/pubmed/27161322
http://dx.doi.org/10.1128/MCB.00199-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936059/
https://www.ncbi.nlm.nih.gov/pubmed/27161322
http://dx.doi.org/10.1128/MCB.00199-16

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