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Early Loss of Telomerase Action in Yeast Creates a Dependence on the DNA Damage Response Adaptor Proteins

Telomeres cap the ends of chromosomes, protecting them from degradation and inappropriate DNA repair processes that can lead to genomic instability. A short telomere elicits increased telomerase action on itself that replenishes telomere length, thereby stabilizing the telomere. In the prolonged abs...

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Detalles Bibliográficos
Autores principales: Jay, Kyle A., Smith, Dana L., Blackburn, Elizabeth H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936065/
https://www.ncbi.nlm.nih.gov/pubmed/27161319
http://dx.doi.org/10.1128/MCB.00943-15