INFα-2b inhibitory effects on CD4(+)CD25(+)FOXP3(+) regulatory T cells in the tumor microenvironment of C57BL/6 J mice with melanoma xenografts

BACKGROUND: Regulatory T cells (Treg(s)), particularly the CD4(+)CD25(+)Foxp3(+) Treg(s), down regulate immunity and promote tumor cell growth by directly suppressing CD8(+) and CD4(+) T cells. Alternatively they can promote tumor growth by generating interleukin-10 (IL-10) and transforming growth f...

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Detalles Bibliográficos
Autores principales: Yu, Yang, Huang, Run, Zong, Xiangyun, He, Xiangming, Mo, Wenju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936163/
https://www.ncbi.nlm.nih.gov/pubmed/27389040
http://dx.doi.org/10.1186/s12885-016-2473-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936163/
https://www.ncbi.nlm.nih.gov/pubmed/27389040
http://dx.doi.org/10.1186/s12885-016-2473-0

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