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INFα-2b inhibitory effects on CD4(+)CD25(+)FOXP3(+) regulatory T cells in the tumor microenvironment of C57BL/6 J mice with melanoma xenografts
BACKGROUND: Regulatory T cells (Treg(s)), particularly the CD4(+)CD25(+)Foxp3(+) Treg(s), down regulate immunity and promote tumor cell growth by directly suppressing CD8(+) and CD4(+) T cells. Alternatively they can promote tumor growth by generating interleukin-10 (IL-10) and transforming growth f...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936163/ https://www.ncbi.nlm.nih.gov/pubmed/27389040 http://dx.doi.org/10.1186/s12885-016-2473-0 |