HIV-1 escapes from N332-directed antibody neutralization in an elite neutralizer by envelope glycoprotein elongation and introduction of unusual disulfide bonds

BACKGROUND: Current HIV-1 immunogens are unable to induce antibodies that can neutralize a broad range of HIV-1 (broadly neutralizing antibodies; bNAbs). However, such antibodies are elicited in 10–30 % of HIV-1 infected individuals, and the co-evolution of the virus and the humoral immune responses...

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Detalles Bibliográficos
Autores principales: van den Kerkhof, Tom L. G. M., de Taeye, Steven W., Boeser-Nunnink, Brigitte D., Burton, Dennis R., Kootstra, Neeltje A., Schuitemaker, Hanneke, Sanders, Rogier W., van Gils, Marit J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936165/
https://www.ncbi.nlm.nih.gov/pubmed/27388013
http://dx.doi.org/10.1186/s12977-016-0279-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936165/
https://www.ncbi.nlm.nih.gov/pubmed/27388013
http://dx.doi.org/10.1186/s12977-016-0279-4

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