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RhoA deficiency disrupts podocyte cytoskeleton and induces podocyte apoptosis by inhibiting YAP/dendrin signal

BACKGROUND: Podocyte apoptosis is a major mechanism that leads to proteinuria in many kidney diseases. However, the concert mechanisms that cause podocyte apoptosis in these kidney diseases are not fully understood. RhoA is one of Rho GTPases that has been well studied and plays a key role in regula...

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Detalles Bibliográficos
Autores principales: Huang, Zongshun, Zhang, Li, Chen, Yuanhan, Zhang, Hong, Yu, Chunping, Zhou, Fangjian, Zhang, Zhiling, Jiang, Lijuan, Li, Ruizhao, Ma, Jianchao, Li, Zhuo, Lai, Yuxiong, Lin, Ting, Zhao, Xinchen, Zhang, Qianmei, Zhang, Bin, Ye, Zhiming, Liu, Shuangxin, Wang, Wenjian, Liang, Xinling, Liao, Ruyi, Shi, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936208/
https://www.ncbi.nlm.nih.gov/pubmed/27389190
http://dx.doi.org/10.1186/s12882-016-0287-6