Topoisomerase I in Human Disease Pathogenesis and Treatments

Mammalian topoisomerase 1 (TOP1) is an essential enzyme for normal development. TOP1 relaxes supercoiled DNA to remove helical constraints that can otherwise hinder DNA replication and transcription and thus block cell growth. Unfortunately, this exact activity can covalently trap TOP1 on the DNA th...

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Detalles Bibliográficos
Autores principales: Li, Min, Liu, Yilun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936607/
https://www.ncbi.nlm.nih.gov/pubmed/27181710
http://dx.doi.org/10.1016/j.gpb.2016.02.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936607/
https://www.ncbi.nlm.nih.gov/pubmed/27181710
http://dx.doi.org/10.1016/j.gpb.2016.02.004

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