Classification model of amino acid sequences prone to aggregation of therapeutic proteins

BACKGROUND: Total body clearance of biological drugs is for the most part dependent on the receptor mechanisms (receptor mediated clearance) and the concentration of antibodies aimed at administered drug – anti-drug-antibodies (ADA). One of the significant factors that induces the increase of ADA le...

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Detalles Bibliográficos
Autores principales: Marczak, Monika, Okoniewska, Krystyna, Grabowski, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937009/
https://www.ncbi.nlm.nih.gov/pubmed/27388622
http://dx.doi.org/10.1186/s40203-016-0019-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937009/
https://www.ncbi.nlm.nih.gov/pubmed/27388622
http://dx.doi.org/10.1186/s40203-016-0019-4

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