Controlled bile acid exposure to oesophageal mucosa causes up-regulation of nuclear γ-H2AX possibly via iNOS induction

Using an in vitro model in which flatmounts of oesophagus was periodically exposed to bile acids, we demonstrate, using multiple methods, that the bile acid receptor TGR5, inducible nitric oxide synthase (iNOS) and γ-histone family 2A variant (γ-H2AX) are up-regulated. This indicates that bile acids...

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Detalles Bibliográficos
Autores principales: Jiang, Bo, Zhao, Shengqian, Tao, Zhen, Wen, Jin, Yang, Yancheng, Zheng, Yin, Yan, Hongling, Sheng, Ying, Gao, Aimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2016
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937172/
https://www.ncbi.nlm.nih.gov/pubmed/27247425
http://dx.doi.org/10.1042/BSR20160124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937172/
https://www.ncbi.nlm.nih.gov/pubmed/27247425
http://dx.doi.org/10.1042/BSR20160124

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