Spironolactone promotes autophagy via inhibiting PI3K/AKT/mTOR signalling pathway and reduce adhesive capacity damage in podocytes under mechanical stress

Mechanical stress which would cause deleterious adhesive effects on podocytes is considered a major contributor to the early progress of diabetic nephropathy (DN). Our previous study has shown that spironolactone could ameliorate podocytic adhesive capacity in diabetic rats. Autophagy has been repor...

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Detalles Bibliográficos
Autores principales: Li, Dong, Lu, Zhenyu, Xu, Zhongwei, Ji, Junya, Zheng, Zhenfeng, Lin, Shan, Yan, Tiekun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2016
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937173/
https://www.ncbi.nlm.nih.gov/pubmed/27129295
http://dx.doi.org/10.1042/BSR20160086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937173/
https://www.ncbi.nlm.nih.gov/pubmed/27129295
http://dx.doi.org/10.1042/BSR20160086

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