Force regulated dynamics of RPA on a DNA fork

Replication protein A (RPA) is a single-stranded DNA binding protein, involved in most aspects of eukaryotic DNA metabolism. Here, we study the behavior of RPA on a DNA substrate that mimics a replication fork. Using magnetic tweezers we show that both yeast and human RPA can open forked DNA when su...

Descripción completa

Detalles Bibliográficos
Autores principales: Kemmerich, Felix E., Daldrop, Peter, Pinto, Cosimo, Levikova, Maryna, Cejka, Petr, Seidel, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937307/
https://www.ncbi.nlm.nih.gov/pubmed/27016742
http://dx.doi.org/10.1093/nar/gkw187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937307/
https://www.ncbi.nlm.nih.gov/pubmed/27016742
http://dx.doi.org/10.1093/nar/gkw187

Ejemplares similares