The structure of ends determines the pathway choice and Mre11 nuclease dependency of DNA double-strand break repair

The key event in the choice of repair pathways for DNA double-strand breaks (DSBs) is the initial processing of ends. Non-homologous end joining (NHEJ) involves limited processing, but homology-dependent repair (HDR) requires extensive resection of the 5′ strand. How cells decide if an end is channe...

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Detalles Bibliográficos
Autores principales: Liao, Shuren, Tammaro, Margaret, Yan, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937313/
https://www.ncbi.nlm.nih.gov/pubmed/27084932
http://dx.doi.org/10.1093/nar/gkw274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937313/
https://www.ncbi.nlm.nih.gov/pubmed/27084932
http://dx.doi.org/10.1093/nar/gkw274

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