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The structure of ends determines the pathway choice and Mre11 nuclease dependency of DNA double-strand break repair
The key event in the choice of repair pathways for DNA double-strand breaks (DSBs) is the initial processing of ends. Non-homologous end joining (NHEJ) involves limited processing, but homology-dependent repair (HDR) requires extensive resection of the 5′ strand. How cells decide if an end is channe...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937313/ https://www.ncbi.nlm.nih.gov/pubmed/27084932 http://dx.doi.org/10.1093/nar/gkw274 |